Cimicifuga racemosa extract Ze 450 shifts macrophage immunometabolism and attenuates pro-inflammatory signaling
Madeline Günther, Nicole Paczia, Susanne Michels, Bernd L. Fiebich, Sebastian Vogt, Jürgen Drewe, Georg Boonen, Veronika Butterweck, Carsten Culmsee
Highlights
- Ze 450 promotes metabolic reprogramming of macrophages.
- Ze 450 blocks NO-signaling and cytokine production.
- Ze 450 extract modulates TCA cycle and electron transport chain activity.
- Reduced HIF-1α and mTOR expressions contribute to anti-inflammatory effects of Ze 450
Abstract
Extracts from the rhizomes of Cimicifuga racemosa (CRE) are well-studied for treating climacteric symptoms and considered as a safe alternative to hormone replacement therapy (HRT). Chronic low-grade inflammation, or “inflammaging,” resulting from …