^{Recent news}

"Pharmacological inhibition of Akt and downstream pathways modulates the

expression of COX-2 and mPGES-1 in activated microglia." - Published in:
J Neuroinflammation

2012 Jan 3

^{Opinions from our customers:}

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

"We cooperate very well since many years and learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."

IN VITRO TOXICITY TESTING

zellkultur toxi

In vitro models:
- V79 cells (parental),
- Recombinant V79 cells (expressing phase I and phase II enzymes)
S. typhimurium(TA97a, TA98, TA100, TA102, TA104, TA1535, TA1537, TA1538)

In vitro assays:
- Cytotoxicity (MTT, Neutral Red, Sulforhodamine)
- HPRT test (OECD Guidline 476)
- Ames test (OECD Guidline 471)
- Chromosomal aberration test (OECD Guidline 473)
- Mouse lymphoma test (OECD Guidline 476)
- Micronucleus test (OECD Guidline 474)
- Sister chromatid exchange test (OECD Guidline 479)
- Comet assay
- DNA adduct test

- IN VIVO TOXICITY TESTING (GLP)

- Systemic toxicity (acute, subacute, subchronic)
- Reproduction toxicity / Teratogenicity
- Contact sensitization