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vivacell_graurotbuttonklein  Recent news


"Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1ß-stimulated SK-N-SH neuronal cells."
J Ethnopharmacol. 2014 Jan 31


"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28


"Controlled type II diabetes mellitus has no major influence on platelet micro-RNA expression. Results from micro-array profiling in a cohort of 60 patients."
Thromb Haemost. 2013 Dec 19


 

 

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vivacell_graurotbuttonklein  Opinions from our customers:

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Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

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"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

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 MUSCLE

  muscle


In vivo models adapted for Nutraceutical Research

- Myotoxicity: experimental myological alterations induced by different chemical toxicants.
- Muscle hypertrophy: treadmill running, surgical ablation of a muscle synergist.
- Muscle atrophy: denervation (chronic or transient), immobilisation, tenotomy, …
- Muscle degeneration and regeneration: several experimental procedures are available: chemical (intramuscular injection of toxins or local anaesthetics) and physical (cold, contusion, strains, exercise),..
- Exercise: chronic and acute exercise; eccentric and concentric exercise,..
- Nutrition: deprivation, hypocaloric and hypoproteic diets
Muscle ageing: study of sarcopenia (gradual loss of muscle fibres and decrease in fibre size) in several muscles.

 

Parameters:
- Histological techniques (H&E, modified Gomor trichrome, Van Giesson, toluidine blue for semithin sections,…)
- Histochemical techniques (PAS, Oil Red O, NADH-tr, myofibrilar ATPase, SDH, acid phosphatase, alkaline phosphatase, phosphorylase, ..)
- Inmunohistochemical techniques (myosin isoforms, desmin, MyoD, myogenin, etc…)
- Electron microscopic analysis: ultrastructural morphology
Morphometric analysis: muscle fibre size (area and minimum diameter), form factor, fibre types frequency, capillary density, incidence of pathologically altered muscle fibres, ultrastructural morphometry,…

 

 

 

 

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