^{Recent news}

"Pharmacological inhibition of Akt and downstream pathways modulates the

expression of COX-2 and mPGES-1 in activated microglia." - Published in:
J Neuroinflammation

2012 Jan 3

^{Opinions from our customers:}

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

"We cooperate very well since many years and learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."

Publications - Cancer/Oncology

2009

Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells.

Sánchez-Duffhues G, Calzado MA, de Vinuesa AG, Appendino G, Fiebich BL, Loock U, Lefarth-Risse A, Krohn K, Muñoz E.

Biochem Pharmacol. 2009 Apr 15;77(8):1401-9. Epub 2009 Jan 21.

2005

Aiello A, Fatorusso E, Luciano P, Macho A, Menna M, Muñoz E. Antitumoral effects of two novel unique naturally occurring terpene quinones isolated from the Mediterranean ascidian Aplidium Conicum. J.Med-Chem. 2005 In press.

Pajonk F, Scholber J, Fiebich B. Hypericin-an inhibitor of proteasome function. Cancer Chemother Pharmacol. 2005 May;55(5):439-46. Epub 2005 Jan 26.

2004

Macho A, Blanco-Molina M, Spagliardi P, Appendino G, Bremner P, Heinrich M, Fiebich BL, Muñoz E. Identification of Ca2+ Ionophoretic and Apoptotic Daucanes from Giant Fennel (Ferula communis L.). Biochem. Pharmacol. 2004 Sep 1;68(5):875-83.

2003 and before

Sancho R, de la Vega L, Appendino G, Di Marzo V, Macho A, Munoz E. The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway. Br J Pharmacol. 2003 Nov;140(6):1035-44. Epub 2003 Oct 6.

Macho A, Sancho R, Minassi A, Appendino G, Lawen A, Munoz E. Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells. Free Radic Res. 2003 Jun;37(6):611-9.

Macho A, Lucena C, Sancho R, Daddario N, Minassi A, Munoz E, Appendino G. Nonpungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential. Eur J Nutr. 2003 Jan;42(1):2-9.

Blanco-Molina M, Tron GC, Macho A, Lucena C, Calzado MA, Munoz E, Appendino G. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway. Chem Biol. 2001 Aug;8(8):767-78.

Gajate C, Santos-Beneit AM, Macho A, Lazaro MC, Hernandez de Rojas A, Modolell M, Muñoz E, Mollinedo F. Involvement of mitochondria and caspase-3 in ET-18-OCH3 induced apoptosis of human leukemic cells. Int. J. Cancer 2000 86, 208-218