^{Recent news}

"Pharmacological inhibition of Akt and downstream pathways modulates the

expression of COX-2 and mPGES-1 in activated microglia." - Published in:
J Neuroinflammation

2012 Jan 3

^{Opinions from our customers:}

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

"We cooperate very well since many years and learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."

ADME /

DRUG METABOLISM

adme organe

DRUG METABOLISM (GLP)

Human hepatocytes, rat hepatocytes, microsomes
Cell lines with stable expression of Cytochrome P450-isoenzymes
Cell lines with stable expression of phase II-enzymes (sulfotransferases)

Parameters:
Cytotoxicity (human hepatocytes)
Metabolic stability
Induction (mRNA-level, activity level)
Inhibition (screen, IC50, Ki)

P-GLYCOPROTEIN (PGP)
Pgp induction / inhibition assay
Caco-2 cells, LS180 cells
primary bovine brain capillary endothelial cells

Parameters:
Transport activity (rhodamine 123, pgp substrate)
Transport activity (pgp substrate)
Protein level (Western blot)

PHARMACOKINETICS (ADME) <top>

Pharmacokinetic studies with respect to ADME and distribution into organs (rodents).

In vivo models:
Rats, mice, guinea pigs, hamsters

Parameters:
Individual blood level time profile
Mean blood level time profile 96 h i.v./p.o.
Distribution of radioactivity into cells and plasma
Distribution of radioactive test compound into organs
Excretion of urine, faeces total, excretion into bile
Metabolic pattern by DC