^{Recent news}

"Pharmacological inhibition of Akt and downstream pathways modulates the

expression of COX-2 and mPGES-1 in activated microglia." - Published in:
J Neuroinflammation

2012 Jan 3

^{Opinions from our customers:}

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

"We cooperate very well since many years and learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."

PERMEABILITY STUDIES (GLP)

Gastrointestinal absorption
Human colon carcinoma cell line (Caco-2)
Measurement of subst./formulation-dependent conc. vs. time profiles (permeation proc.)
Permeability measurements for BCS classification
Testing the barrier function (investigating toxic effects)
Determining the permeation mechanism

Blood-Brain Barrier (BBB)
Primary cultures of porcine cerebral endothelial cells
Tests of the retardation of active ingredients and drug metabolites through BBB
Testing the barrier function (e.g. cytotoxicity testing)
Experimental investigations with and without serum proteins
Investigation of active carrier systems

Dermal systems
Human skin or porcine skin
Franz cell method / Saarbrücken dermal penetration model
Measurement of substance-dependent concentration vs. time profiles of the permeation
Measurement of substance-dependent concentration vs. penetration depth profiles
In vitro3T3 NRU Cytotoxicity testing / In vitro3T3 NRU Phototoxicity testing