Phytodrugs / Nutraceuticals

Immunology / Inflammation / AIDS

CNS

Cancer / Oncology

Metabolism

Chemistry

Aktuelle Veröffentlichungen

Publications - Immunology / Inflammation / AIDS

2008

 

Mousavizadeh K, Stratz T, Mueller W, Fiebich BL. 5-HT3 receptor antagonist for the treatment of tendinopathy. Nat Clin Pract Rheumatol. 2008 Jun;4(6):E4. No abstract available.

 

Stratz C, Trenk D, Bhatia HS, Valina C, Neumann FJ, Fiebich BL. Identification of 5-HT3 receptors on human platelets: Increased surface immunoreactivity after activation with adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP). Thromb Haemost. 2008 Apr;99(4):784-6.

 

2007

 

Seidel MF, Fiebich BL, Ulrich-Merzenich G, Candelario-Jalil E, Koch FW, Vetter H. Serotonin mediates PGE(2) overexpression through 5-HT(2A) and 5-HT (3) receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. Rheumatol Int. 2008 Mar 27

 

Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Mol Pharmacol. 2007 Dec;72(6):1657-64. Epub 2007 Sep 25.

 

2005 and before

 

Marquez N, Sancho R, Bedoya LM, Alcami J, Lopez-Perez JL, Feliciano AS, Fiebich BL, Munoz E. Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway. Antiviral Res. 2005 Jun;66(2-3):137-45.

 

Vega LD, Munoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, Farber L, Mueller W, Stratz T, Fiebich BL. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005 May 26.

 

Fiebich BL, Akundi RS, Lieb K, Candelario-Jalil E, Gmeiner D, Haus U, Muller W, Stratz T, Munoz E. (2004) Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide- stimulated primary human monocytes. Scand J Rheumatol Suppl. 2004:28-32.

 

Marquez N, Sancho R, Ballero M, Bremner P, Appendino G, Fiebich BL, Heinrich M, Munoz E. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT. Planta Med. 2004 Nov;70(11):1016-21.

 

Sancho R, Macho A, de La Vega L, Calzado MA, Fiebich BL, Appendino G, Munoz E. (2004). Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappaB, NFAT, and activator protein 1 signaling pathways. J Immunol;172:2341-51.

 

Sancho R, Medarde M, Sanchez-Palomino S, Madrigal BM, Alcami J, Munoz E, San Feliciano A. Anti-HIV activity of some synthetic lignanolides and intermediates. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4483-6.

 

Sancho R, Marquez N, Gomez-Gonzalo M, Calzado MA, Bettoni G, Coiras MT, Alcami J, Lopez-Cabrera M, Appendino G, Munoz E. Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. J Biol Chem. 2004 Sep 3;279(36):37349-59.

 

Calzado MA, Sancho R, Muñoz E. HIV-1 Tat increases the expression of Cleavage and Polyadenylation Specificity Factor 73 kDa subunit modulating cellular and viral expression. J. Virology 2004 78; 6846-54

 

Marquez N, Sancho R, Macho A, Calzado MA, Fiebich BL, Munoz E. Caffeic acid phenethylester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J Pharmacol Exp Ther. 2004 308:993-1001.

 

Norgauer J, Ibig Y, Gmeiner D, Herouy Y, Fiebich BL. Prostaglandin E2 synthesis in human monocyte-derived dendritic cells. Int J Mol Med. 2003 Jul;12(1):83-6.

 

Ulbrich H, Fiebich B, Dannhardt G. Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type. Eur J Med Chem. 2002 Dec;37(12):953-9.

 

Sancho R, Lucena C, Macho A, Calzado MA, Blanco-Molina M, Minassi A, Appendino G, Muñoz, E. Immunosuppressive activity of capsaicinoids. Capsiate derived from sweet peppers inhibits NF-B activation and is a potent anti-inflammatory compound in vivo. Eur. J. Immunol. 2002 32, 1753-1763

 

Fiebich BL, Heinrich M, Hiller K.O., Kammerer N. Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 2001 8, 28-30.

 

Dannhardt G, Kiefer W, Krämer G, Maehrlein S, Nowe U, Fiebich B. The pyrroly moiety as a template for COX-1/COX-2 inhibitors. Eur. J. Med. Chem. 2000 35, 499-510.