^{Recent news}

"Pharmacological inhibition of Akt and downstream pathways modulates the

expression of COX-2 and mPGES-1 in activated microglia." - Published in:
J Neuroinflammation

2012 Jan 3

^{Opinions from our customers:}

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

"We cooperate very well since many years and learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."

CENTRAL NERVOUS

SYSTEM

nervensystem

In vivo models
- Stroke:Transient or permanent occlusion of the middle cerebral artery in rat, mouse, and transgenic rodents, focal ischemia in gerbils

- Cardiac arrest:Occlusion of both carotid and vertebral arteries in rat and gerbil
- Head trauma:Controlled cortical impact injury in rat and mouse
- Spinal cord trauma:With a spinal cord impactor in rat
- Parkinson's disease:Intracerebral injection of 6-OH dopamine in rat and mouse
- Epilepsy:Systemic/hippocampal kainic acid injection in rat and mouse
- Huntington's disease:Intrastriatal injection of quinolinate in rat and mouse
- Migraine:Spreading depression induced by KCl in rat and mouse
- Brain edema: Cold-injury -induced in rat and mouse
- Neuromuscular/neurological models:Multiple sclerosis (EAE), transgenic models for ALS
- Brain ventricular canalization for drug delivery

Others on request

In vitro models
-Primary microglia/astrocytes/neurons/oligodendrocytes (rat, murine) astrocytoma cell lines, human neuronal cell lines
Brain slice cultures, synaptosomes
-293T /CHO cells with heterologous expression of the Vanilloid Receptor type 1 (TPRV-1)